Eurotau2021 meeting
October 25, 2021
Welcome address:
8:30-9:00 – Luc Buée and RCF representative
9:00-11:00 Session 1 (Chairs: A. Rovelet-Lecrux & J. Attems)
9:00 – Johannes Attems (UK) Tau in ageing/ AD/ PART and frontotemporal lobar degeneration
9:15 – Anne Rovelet-Lecrux (France) Clinical and neuropathological diversity of tauopathy in MAPT duplication carriers
9:30 – Ruiqing Ni (Switzerland) High-resolution non-invasive whole brain optoacoustic tomography imaging of tau in P301L tauopathy mice
9:40 – Tiago Gil Oliveira (Portugal) Primary age-related tauopathy (PART) and Alzheimer’s disease show differential magnetic resonance imaging atrophy patterns
9:50 – Eugeen Vanmechelen (Belgium) Two plasma p-tau SIMOA-based assays using a shared synthetic calibrator peptide for detection of AD pathology
10:00 – Roberto Simone (UK) Natural antisense transcripts containing an embedded mammalian-wide interspersed repeat repress MAPT translation and aid proteostasis in neurodegeneration
10:15 – Karine Cambon (France) Neuronal Tau pathology transfers to astrocytes and induces their loss according to Tau aggregation state in mouse models
10:25 – Kevin Richetin (Switzerland) Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease
10:35 – Michael Heneka (Germany-Luxembourg) How microglia modulate tau pathology
10:50 – Questions
11:00-11:30 Coffee break
11:30-13:00 Rainwater Prize ceremony
11:30 – Introduction
11:35 – Richard Carmona – Prize overview
11:50 – Philippe Amouyel (Chairperson: L Buée) – JPND & European funding for NDD
12:15 – Celeste Karch, Rainwater Prize for Innovative Early Career Scientist (Chair: Leonard Petrucelli)
12:30 – David Holtzman, Rainwater Prize forOutstanding Innovation in Neurodegenerative Disease Research (Chairperson: Howard Feldman)
12:45 – Todd and Matt Rainwater thank winners, nominators, scientists
12:55 – Amy Rommel – About prize & nominations open
12:59 – Luc Buee closes the Rainwater Ceremony
13:00-14:30 Lunch & Poster exhibition
14:30-16:00 Session 2 (Chairs: A. Rommel & L. Buée)
14:30 – David Holtzman, 2020 Rainwater Prize forOutstanding Innovation in Neurodegenerative Disease Research (USA)
14:50 – Michel Goedert, 2019 Rainwater Prize forOutstanding Innovation in Neurodegenerative Disease Research (UK) Cryo-EM structures of amyloid filaments from human brain
15:10 – Celeste Karch, 2020 Rainwater Prize for Innovative Early Career Scientist (USA) Molecular and cellular drivers of tauopathy
15:30 – Mathieu Bourdenx (France) Chaperone-mediated autophagy: a gatekeeper of neuronal proteostasis
15:40 – Wiep Scheper (The Netherlands) Cell type-specific proteostatic responses to tau pathology
15:50 – Lukasz A Joachimiak (USA) DnaJC7 binds natively forlded structural elements in tau to inhibit amyloid formation
16:00-16:30 Coffee break
16:30-18:00 Session 3 (Chairs: I. Landrieu & Y. Fichou)
16:30 – Illana Gozes (Israel) Novel insights to ADNP/NA/Tau protein interactions dictating brain development and aging
16:40 – Eliana Nachman (Belgium) Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species
16:50 – François Devred (France) Three zinc binding sites of Tau and their role in tau aggregation
17:00 – Cláudio M. Gomes (Portugal) Dynamic interactions and Ca2+-binding modulate the chaperone activity of S100B preventing tau aggregation and seeding
17:10 – Davide Tampellini (France) Enhancement of synaptic stimulation induces tau clearance via the autophagosomal/lysosomal pathway
17:20 – Marina Rierola (Germany) Tau shapes microtubule-dependent transport in the dendrites
17:30 – Laura Vallés Saiz (Spain) Tau expression in the kidney: cell distribution and physiological function
17:40 – Marie Galas (France) Revisiting the link between tau and the neuronal cell cycle in Alzheimer’s disease: an unexpected role for nuclear tau
17:50 – Mahmoud Maina (UK / USA) The involvement of Tau in nucleolar function and stress response
18:00-20:00 Rainwater Prize reception (OPEN to all Eurotau participants)
October 26, 2021
8:30-9:00 – Plenary lecture
Kenneth Kosik (USA) A Rite of Passage: Tau’s Route Between And Within Cells
9:00-11:00 – Session 4 (Chairs: A. Mudher & I. Ferrer)
9:00 – Eckhard Mandelkow (Germany) Recent insights into Tau seeding and phosphorylation
9:15 – Louise Serpell (UK) The role of the core of tau paired helical filaments in AD and other tauopathies
9:25 – Yann Fichou (France) Tau intertwines with cofactors: how it modulates complex phase separation, oligomerization & aggregation properties
9:35 – Susanne Wegmann (Germany) Condensating the interactions of tau
9:45 – Amrit Mudher (UK) Tau aggregation and spread of pathology in Drosophila
9:55 – Isidre Ferrer (Spain) Importance of host tau in tau seeding and spreading in tauopathies
10:05 – Marie-Ange De Fisenne (Belgium) Alzheimer PHF-tau do not spread tau pathology to the brain via the retinotectal pathway after intraocular injection in mouse models
10:15 – Marc Dhenain (France) Induction of tau lesions in amyloid-bearing mice and in primates after inoculation of Alzheimer brain extracts
10:25 – Evgeni Ponimaskin (Germany) Amelioration of Tau pathology and memory deficits by targeting serotonin receptors
10:35 – Diane Hanger (UK) Truncated tau as a model of human tauopathy
10:50 – Questions
11:00-11:30 Coffee break
11:30-13:00 Session 5 (Chairs: D. Hanger & E. Mandelkow))
11:30 – Selected communication
11:40 – Selected communication
11:50 – Selected communication
12:00 – Selected communication
12:10 – Selected communication
12:20 – Selected communication
12:30 – Selected communication
12:40 – Selected communication
12:50 – Questions
13:00-14:30 Lunch & Poster exhibition
14:30-16:00 Session 6 (Chairs: S. Wegmann & M. Dhenain)
14:30 – Karen Duff (UK) Mechanistic underpinnings of selective cellular vulnerability to tauopathy
14:45 – Elodie Leroux (France) Extracellular vesicles and tau seeding among tauopathies
14:55 – Dirk Beher (Switzerland) OGA inhibitors as multimodal drug candidates for tau- and alpha-synucleinopathies15:30 – –
15:10 Norbert Zilka (Slovakia) Tau vaccine AADvac1 trains immune system to produce therapeutic antibodies against disease tau species in Phase II clinical trial
15:25 – Isabelle Landrieu (France) Single domain antibody fragments: new tools for studying Tau as a target for therapy
15:35 – John Sotiropoulos (Portugal) A novel method of spontaneously-released extracellular vesicles isolation from mouse and human brain
15:45 – Marco Luppi (Italy) Deep hypothermia stimulates a neuroprotective process reversing the accumulation of hyperphosphorylated tau protein in the rat hippocampus
15:55 – Questions
16:00-16:30 Coffee break
16:30-17:00 Session FLASH TALKS (Chairs: to be confirmed)
16:30 – Flash talk – selected poster
16:35 – Flash talk – selected poster
16:40 – Flash talk – selected poster
16:45 – Flash talk – selected poster
16:50 – Flash talk – selected poster
16:55 – Flash talk – selected poster
17:00 Poster prize
Lille
