Programme

If your research or clinical activity drives you into the field of CHANNELOPATHIES, don’t miss the unique international event « Channelopathy 2016 » that will take place in Paris:  World-renowned speakers, pioneers in the field of channelopathies, will present their latest discoveries (check the online program: Program)!
Because the meeting is limited to 180 attendees, registrations will be taken on a first-come first-served basis. So we strongly recommend to register as early as possible! (Online registration: Registration) Registration fees include the get-together party on Wednesday evening, as well as Thursday and Friday breaks and lunches.
Key dates at-a-glance:
Early-bird registration deadline: April 30, 2016
Late registration deadline: June 13, 2016
Meeting: June 15-17, 2016

Chairperson: Christophe MULLE

CNRS UMR 5297, Université de Bordeaux, 146, rue Léo-Saignat, 33077 Bordeaux cedex, France
Phone: +33 (0) 5 57 57 40 80 – Fax: +33 33 (0) 5 57 57 40 82
Email

Vice-chairperson: Frijhof HELMCHEN

Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland
Phone: +41 44 63 53 340 – Fax: +41 44 63 53 303
Email

Discovering how neural circuits process information requires measurement of neural activity on many different scales, ranging from single synapses to large assemblies of neurons, best in the brain of behaving animals. The study of brain function at the microscopic and mesoscopic scale has been revolutionized by novel approaches combining the development of molecular tools and gene transfer methods with newly designed instruments that use light to visualize and manipulate the activity of synapses, neural cells and neural ensembles. This international symposium will bring together world experts to present their latest discoveries and technological developments regarding brain connectivity, focusing on studies of synaptic, neuronal and network structure and function using microscopic imaging, connectomics, and optogenetics.

Improved technologies in the field of neuroscience are particularly important to tackle the great challenges in mapping the connections and interactions within and between highly complex neuronal networks. For example, super-resolution light microscopy now enables the visualization of individual molecules within a synapse; novel 3D imaging approaches enable the mapping of synaptic inputs onto dendritic trees and signalling within neuronal populations to be ‘read out’ at millisecond time scales; new viral tracing methods and novel instruments based on automated electron microscopy, optical microscopy and image reconstruction methods assist comprehensive connectomic approaches towards full reconstruction and analysis of synaptic circuits in 3D; furthermore, fast two-photon imaging makes it possible to monitor neural network activity deep in tissue in behaving animals; and recent advances in optogenetic and pharmacogenetic methods are complementing structural and functional imaging by allowing specific manipulations of the activity of particular cell types or neural pathways.

These multidisciplinary challenges and many others will be addressed at this meeting. It will be a great opportunity to foster new collaborations to undertake novel challenges that will push further our ability to detect, measure, manipulate and follow the intricate components of neuronal and network function.
Invited speakers
(provisional titles)

BAILLY-CUIF Laure (Gif sur Yvette, France)
Imaging neural progenitor cells dynamics during behavior

BITO Haruhiko (Tokyo, Japan)
Labeling, monitoring and manipulating active ensembles

CHEDOTAL Alain (Paris, France)
Development of new imaging methods to study the organization of sensory systems

CHOQUET Daniel (Bordeaux, France)
Nanoscopic organization of synapses

COSSART Rosa (Marseille, France)
Imaging ripple events in the awake mouse hippocampus

EMILIANI Valentina (Paris, France)
Two-photon optogenetics by spatio-temporal shaping of ultrafast pulse

FRICK Andreas (Bordeaux, France)
Neuronal circuits probed with recombinant rabies virus technology

GRADINARU Viviana (Pasadena, USA)
Brain control with light; development and application to mental disorders

HELMCHEN Fritjof (Zürich, Switzerland)
Imaging cortical circuit dynamics in behaving mice

HOFER Sonja (Bazel, Switzerland)
Imaging function and structure of the visual system

HOLTMAAT Anthony (Geneva, Switzerland)
Neural circuits in the mammalian neocortex

ISACOFF Ehud Y. (Berkeley, USA)
Design of novel probes for the optical detection and manipulation of neuronal signaling

KIM Jinny (Seoul, South Corea)
mGRASP for mapping connectivity at multiple scales

KONNERTH Arthur (Tum, Germany)
Impaired neuronal network function in mouse models of Alzheimer’s disease

MARGRIE Troy (London, United Kingdom)
Sensory processing in single cells, circuits and behavior

MONYER Hannah (Heidelberg, Germany)
Connectivity in the entorhinal cortex

NÄGERL Valentin (Bordeaux, France)
Super-resolution imaging of spine plasticity

NEVIDI Elly (Cambridge, USA)
Visualization of synapse assembly and disassembly in vivo: multispectral tracking of distinct circuit elements
OERTNER Thomas (London, United Kingdom)
Controlling the strength and lifetime of synapses with light

PERROY Julie (Montpellier, France)
Imaging plasticity at synapses

RUSAKOV Dmitri (London,United Kingdom)
Mapping  nanomolar calcium landscapes inside neurons and astroglia with FLIM

SILVER Angus (London, United Kingdom)
Investigating the role of temporal coding using high speed 3D 2-photon imaging

SNITZER Mark (Stanford, USA)
Development of fiber-optic fluorescence microendoscopy for studies of learning and memory

STERNSON Scott (Ashburn, USA)
Neural processes that underlie hunger studied with reverse engineering of neural circuits

WILLIG Katrin (Göttingen, Germany)
In vivo STED microscopy of the living mouse brain

WYART Claire (Paris, France)
Investigation of a novel sensory interface relaying information from the cerebrospinal fluid to motor circuits

ZENG Hongkui (Seattle, USA)
Large scale analysis of mouse brain connectivity

Deadline for application: March 7, 2016
Registration fee (including board and lodging)

430 € for PhD students
650 € for other participants

Application for registration
The total number of participants is limited to 115 and all participants are expected to attend for the whole duration of the conference. Selection is made on the basis of the affinity of potential participants with the topics of the conference. Scientists and PhD Students interested in the meeting should send:

– their curriculum vitae
– the list of their main publications for the 3 last years
– the abstract of their presentation

to the Chairperson of the conference (christophe.mulle@u-bordeaux.fr) before the deadline. After it, the organizers will select the participants. Except in some particular cases approved by the Chairperson, it is recommended that all selected participants present their work during the conference, either in poster form or by a brief in- session talk.The organizers choose the form in which the presentations are made. Up to 6 participants will be selected, based on their abstracts, for a short talk. No payment will be sent with application. Information on how and when to pay will be mailed in due time to those selected.

Lake Como School of Advanced Studies, 5-9 June 2016

Amino acids are extremely important molecules in Nature by serving as metabolic intermediates or as building units for proteins synthesis. All common amino acids, except for glycine, exhibit a chiral center resulting theoretically in the occurrence of L- and D-amino acids. Despite almost identical chemical and physical properties, in the past it was assumed that only L-amino acids were selected during evolution for polypeptides and proteins formation. The selection of the L-form was generally thought to result from gambling. The consequent homochirality was considered to be essential to biology, as it dictates the spatial architecture of biological polymer and therefore plays a major role in enzymatic specificity and structural interaction: it generated distinct enzyme/receptors to cope with multiple isomers which would pose energetic burdens incompatible with life.

Since plants and bacteria were known to synthesize D-amino acids, the free D-isomers found in higher animals were assumed to be essentially the by-products of dietary consumption. Therefore, the presence of high levels of enzymes evolved specifically to catalyze the stereoselective degradation of D-amino acids (e.g., FAD-dependent D-amino acid oxidase and D-aspartate acid oxidase) and their significance in the brain, has long been a puzzling issue. Thank to the development of more sensitive analytical techniques, neurobiologists have now stepped “through the looking-glass” and several D-amino acids were detected in mammalian tissues and fluids. In particular, D-aspartate and D-serine have been shown to be endogenously synthesized by serine racemase and aspartate racemase, respectively, and to serve as important signaling molecules in the brain and endocrine glands.

Emerging unanticipated roles for the D-aspartate and D-serine challenged fundamental dogma about cell-to-cell signaling. They both appeared to fulfill the criteria of N-methyl-D-aspartate (NMDA) receptor ligands (as a agonist and coagonist, respectively), regulating the receptor functionality. NMDA subtype of glutamate receptors mediates excitatory neurotransmission and cognitive functions, hence insight into D-serine and D-aspartate metabolism is relevant for physiological NMDA receptor activation and for all the disorders associated with the receptor dysfunction, such as schizophrenia, ischemia, epilepsy, chronic pain and neurodegenerative disorders. In particular, abnormal alterations in the cellular and extracellular concentrations of these two D-amino acids might be related to the pathogenesis of the aforementioned diseases. Accordingly, the detection of D-serine and D-aspartate in the brain and the elucidation of the mechanisms involved in the maintenance of their physiological levels (which might be up- or down-regulated in pathological condition) may not only help in the diagnostic process, but also provide novel therapeutic target.

We are just at the beginning to disclose the importance of this novel class of brain messengers that will soon include other candidates. The proposed Summer School will provide an overview of the current status of our understanding on D-amino acid neurobiology, collecting contributions from leaders in the field.

Invited speakers
BALU Darrick (Boston, USA)
BILLARD Jean-Marie (Paris, France)
BRUNO Stefano (Parma, Italy)
DI GIORGIO Annabella (Foggia, Italy)
ERRICO Francesco (Naples, Italy)
HERESCO-LEVY Uriel (Jerusalem, Israel)
MOLLA Gianluca (Varese, Italy)
MOTHET Jean-Pierre (Marseille, France)
POLLEGIONI Loredano (Varese, Italy)
SACCHI Silvia (Varese, Italy)
SASABE Jumpei (Tokyo, Japan)
SWEEDLER Jonathan (Urbana, USA)
USIELLO Alessandro (Naples, Italy)
WOLOSKER Herman (Haifa, Israel)

For further information, please visit the website.

Emerging Concepts in Glial Cell Research

Organised by

Le Club des Cellules Gliales

Contacts :

brahim.nait_oumesnar@upmc.fr

thierry.amedee@u-bordeaux2.fr

Website

The Sixth International Symposium on Biology of Decision Making will take place on May 25-27, 2016 at the Institut du Cerveau et de la Moelle Epinière, Paris, France, with a satellite day at Ecole Normale Supérieure, Paris, France. The objective of this three day symposium is to gather people from different research fields with different approaches (economics, ethology, psychiatry, neural and computational approaches) to decision-making.

The symposium will be a single-track, will last for 3 days and will include 6 sessions:
(#1) Cost of control, fatigue and decision-making;
(#2) Emotion, stress and decision-making;
(#3) Dynamics of decision-making;
(#4) Decision-making across primates;
(#5) Confidence, mood and decision-making;
(#6) Learning, memory and decision-making.

CONFIRMED SPEAKERS:
Sébastien Bouret (CNRS – ICM, France)
Michael Chee (Duke-NUS Medical School, Singapore)
Anastasia Christakou (University of Reading, UK)
Anne Churchland (Cold Spring Harbor Laboratory, USA)
Stanislas Dehaene (Collège de France – INSERM – CEA, France)
Adele Diederich (Jacobs University, Germany)
Tobias H. Donner (University of Amsterdam, The Netherlands)
Valérie Dufour (CNRS, France)
Shelly Flagel (University of Michigan, USA)
Steve Fleming (University College London, UK)
Birte U. Forstmann (University of Amsterdam, The Netherlands)
Cendri Hutcherson (University of Toronto, Canada)
Veronika Job (University of Zurich, Switzerland)
Mehdi Khamassi (CNRS – Université Pierre et Marie Curie, France)
Pascal Mamassian (Ecole Normale Supérieure – CNRS, France)
Florent Meyniel (Collège de France – INSERM – CEA, France)
Randall O’Reilly (University of Colorado Boulder, USA)
Mathias Pessiglione (INSERM – ICM, France)
Jonathan Pillow (Princeton University, USA)
Timothy J. Pleskac (Max Planck Institute, Germany)
Alexandra G. Rosati (Harvard University, USA)
Robb Rutledge (University College London, UK)
Jérôme Sallet (University of Oxford, UK)
Carmen Sandi (Ecole Polytechnique Fédérale de Lausanne, Switzerland)
Daniela Schiller (Mount Sinaï University, USA)
Amitai Shenhav (Princeton University, USA)
Mark Sheskin (Yale University, USA)
Hiromu Tanimoto (Tohoku University, Japan)
Angela J. Yu (University of California San Diego, USA)
Alexandre Zenon (Université Catholique de Louvain, Belgium)

IMPORTANT DATES:
April 30, 2016 Deadline for Poster Submission
May 7, 2016 Notification of Poster Acceptance
May 15, 2016 Deadline for Registration
May 25-27, 2016 Symposium

ORGANIZING COMMITTEE:
Thomas Boraud (CNRS – IMN, Bordeaux, France)
Sacha Bourgeois-Gironde (La Sorbonne, Paris, France)
Kenji Doya (OIST, Okinawa, Japan)
Mehdi Khamassi (CNRS – UPMC, Paris, France)
Etienne Koechlin (CNRS – ENS, Paris, France)
Mathias Pessiglione (ICM – INSERM, Paris, France)

Website, registration, poster submission and detailed program.

Contact: sbdm2016@isir.upmc.fr / sbdm2016-registration@isir.upmc.fr

Join the Alzheimer’s Drug Discovery Foundation as we bring our popular drug discovery 101 conference to Europe. Attendees will learn what it takes to translate basic research into novel therapies and will leave with resources to address the challenges in developing a drug. The program includes case studies and presentations from European biopharmaceutical companies, including Actelion Pharmaceuticals, Oryzon Genomics, Asceneuron, and Axxam SpA.

Website

Aviesan – Atelier

Plus d’infos