{"id":4851,"date":"2016-05-11T15:08:59","date_gmt":"2016-05-11T14:08:59","guid":{"rendered":"https:\/\/www.neurosciences.asso.fr\/en\/2016\/05\/controle-de-la-fertilite-des-microarns-responsables\/"},"modified":"2022-05-18T16:10:15","modified_gmt":"2022-05-18T14:10:15","slug":"controle-de-la-fertilite-des-microarns-responsables","status":"publish","type":"post","link":"https:\/\/www.neurosciences.asso.fr\/en\/2016\/05\/controle-de-la-fertilite-des-microarns-responsables\/","title":{"rendered":"Contr\u00f4le de la fertilit\u00e9 : des microARNs responsables !"},"content":{"rendered":"

Des ARN particuliers de petites tailles sont responsables du contr\u00f4le de l\u2019expression de la gonadolib\u00e9rine ou GnRH (Gonadotropin Leasing Hormone), une neurohormone qui pilote la maturation sexuelle, l\u2019apparition de la pubert\u00e9 et la fertilit\u00e9 \u00e0 l\u2019\u00e2ge adulte. C\u2019est ce que vient de d\u00e9montrer l\u2019\u00e9quipe \u00ab D\u00e9veloppement et plasticit\u00e9 du cerveau neuroendocrine \u00bb dirig\u00e9e par Vincent Pr\u00e9vot, Directeur de recherche Inserm (Centre Jean-Pierre Aubert, Lille). L\u2019intervention des micro-ARNs, transcrits de l\u2019ADN, s\u2019op\u00e8re autour de la naissance, et marque une \u00e9tape cl\u00e9 du d\u00e9veloppement postnatal. Une d\u00e9faillance de l\u2019action de ces micro-ARNs entraine une perturbation, voire l\u2019arr\u00eat total, de la production de GnRH par les neurones de l\u2019hypothalamus qui la synth\u00e9tise, et ainsi une infertilit\u00e9. Dans les cas les plus graves, une st\u00e9rilit\u00e9 peut intervenir. Le d\u00e9tail de ces travaux sur la souris est publi\u00e9 dans la revue Nature Neuroscience dat\u00e9e du 2 mai 2016.<\/p>\n

Pour en savoir plus, lire le communiqu\u00e9 de presse Inserm<\/a>.<\/p>\n

\u201cA microRNA switch regulates the rise in hypothalamic GnRH production before puberty\u201d
\nAndrea Messina1,2,7, Fanny Langlet1,2,3,9, Konstantina Chachlaki1,2,9, Juan Roa4,5,9, S Rasika6, Nathalie Jouy1,2, Sarah Gallet1,2, Francisco Gaytan4,5, Jyoti Parkash1,2,8, Manuel Tena-Sempere4,5, Paolo Giacobini1,2, Vincent Prevot1,2
\n1 Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre
\nAubert Research Centre, U1172, F-59000 Lille, France
\n2 University of Lille, FHU 1000 days for Health, School of Medicine, Lille, F-59000, France
\n3 Columbia University Medical Center and Berrie Diabetes Center, New York, NY 10032,USA
\n4 Department of Cell Biology, Physiology and Immunology, University of Cordoba & Instituto Maimonides de Investigaci\u00f3n Biom\u00e9dica de Cordoba (IMIBIC\/HURS), 14004 Cordoba,Spain
\n5 CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n, Instituto de Salud Carlos III, 14004 Cordoba, Spain
\n6 Inserm UMR1141 \u2013 PROTECT (Promoting Research Oriented Towards Early CNS Therapies), 75019, Paris, France
\n7 Present address: University of Lausanne, CHUV, Lausanne, Switzerland
\n8 Present address: Centre for Animal Sciences, Central University Punjab, 151001 Bathinda, India
\n9 These authors contributed equally to this work
\nNature Neuroscience, 2 mai 2016, doi:10.1038\/nn.4298<\/p>\n

 <\/p>\n

Contact chercheur<\/strong>
\nVincent Pr\u00e9vot
\nDirecteur de recherche Inserm
\nEquipe \u00ab D\u00e9veloppement et plasticit\u00e9 du cerveau endocrine \u00bb
\nCentre Jean-Pierre Aubert, Unit\u00e9 Inserm 1172, Lille
\nTel: 03 20 62 20 64
\nCourriel <\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Des ARN particuliers de petites tailles sont responsables du contr\u00f4le de l\u2019expression de la gonadolib\u00e9rine ou GnRH (Gonadotropin Leasing Hormone), une neurohormone qui pilote la maturation sexuelle, l\u2019apparition de la pubert\u00e9 et la fertilit\u00e9 \u00e0 l\u2019\u00e2ge adulte. C\u2019est ce que vient de d\u00e9montrer l\u2019\u00e9quipe \u00ab D\u00e9veloppement et plasticit\u00e9 du cerveau neuroendocrine \u00bb dirig\u00e9e par Vincent […]<\/p>\n","protected":false},"author":4,"featured_media":4836,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[31],"class_list":["post-4851","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","tag-actualite-en"],"publishpress_future_action":{"enabled":false,"date":"2026-04-22 07:25:25","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/posts\/4851","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/comments?post=4851"}],"version-history":[{"count":2,"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/posts\/4851\/revisions"}],"predecessor-version":[{"id":17015,"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/posts\/4851\/revisions\/17015"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/media\/4836"}],"wp:attachment":[{"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/media?parent=4851"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/categories?post=4851"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/tags?post=4851"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}