{"id":28619,"date":"2026-02-18T16:52:03","date_gmt":"2026-02-18T14:52:03","guid":{"rendered":"https:\/\/www.neurosciences.asso.fr\/2026\/02\/turn-on-the-heat-le-role-cle-de-notre-temperature-corporelle-dans-la-maladie-dalzheimer\/"},"modified":"2026-02-18T17:35:52","modified_gmt":"2026-02-18T15:35:52","slug":"turn-on-the-heat-le-role-cle-de-notre-temperature-corporelle-dans-la-maladie-dalzheimer","status":"publish","type":"post","link":"https:\/\/www.neurosciences.asso.fr\/en\/2026\/02\/turn-on-the-heat-le-role-cle-de-notre-temperature-corporelle-dans-la-maladie-dalzheimer\/","title":{"rendered":"Turn on the Heat ! Le r\u00f4le cl\u00e9 de notre temp\u00e9rature corporelle dans la maladie d\u2019Alzheimer"},"content":{"rendered":"<p>Notre cerveau fonctionne mieux quand ses grands rythmes physiologiques sont stables, notamment le sommeil et la temp\u00e9rature corporelle. Dans notre \u00e9tude publi\u00e9e dans JCI, nous montrons que de petites variations de temp\u00e9rature, dans une gamme compatible avec la vie quotidienne (par exemple selon l\u2019\u00e9tat veille\/sommeil), peuvent modifier la lib\u00e9ration de la prot\u00e9ine tau par les neurones. Or, tau est une prot\u00e9ine cl\u00e9 impliqu\u00e9e dans la maladie d\u2019Alzheimer lorsqu\u2019elle s\u2019accumule et se d\u00e9r\u00e8gle.<\/p>\n<p>Nos r\u00e9sultats sugg\u00e8rent que la temp\u00e9rature n\u2019est pas un simple &#8220;d\u00e9tail&#8221; exp\u00e9rimental : c\u2019est un levier biologique capable d\u2019influencer la dynamique de tau et, potentiellement, sa propagation dans le cerveau. \u00c0 terme, ce travail ouvre la voie \u00e0 une meilleure compr\u00e9hension des liens entre rythmes circadiens, thermor\u00e9gulation, sommeil et vuln\u00e9rabilit\u00e9 aux maladies neurod\u00e9g\u00e9n\u00e9ratives. Ces r\u00e9sultats ouvrent \u00e9galement la voie \u00e0 des strat\u00e9gies non pharmacologiques compl\u00e9mentaires et non invasives telles que la th\u00e9rapie thermale.<\/p>\n<p>&nbsp;<\/p>\n<p>Contact: <a href=\"mailto:geoffrey.canet@igf.cnrs.fr\">geoffrey.canet@igf.cnrs.fr<\/a> ; Institut de G\u00e9nomique Fonctionnelle (CNRS\/Inserm\/Universit\u00e9 de Montpellier).<\/p>\n<p>&nbsp;<\/p>\n<p>Canet G, Da Gama Monteiro F, Rocaboy E, Diego-Diaz S, Khelaifia B, Godbout K, Lachhab A, Kim J, Valencia DI, Yin A, Wu HT, Howell J, Blank E, Lalibert\u00e9 F, Fortin N, Boscher E, Fereydouni-Forouzandeh P, Champagne S, Guisle I, H\u00e9bert SS, Pernet V, Liu H, Lu W, Debure L, Rapoport DM, Ayappa I, Varga AW,Parekh A, Osorio RS, Lacroix S, Burns MP, Lucey BP, Blessing EM, Planel E. Sleep-wake variation in body temperature regulates tau secretion and correlates with CSF and plasma tau. J. Clin. Invest. 2025 135, e182931. doi: 10.1172\/JCI182931.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Notre cerveau fonctionne mieux quand ses grands rythmes physiologiques sont stables, notamment le sommeil et la temp\u00e9rature corporelle. Dans notre \u00e9tude publi\u00e9e dans JCI, nous montrons que de petites variations de temp\u00e9rature, dans une gamme compatible avec la vie quotidienne (par exemple selon l\u2019\u00e9tat veille\/sommeil), peuvent modifier la lib\u00e9ration de la prot\u00e9ine tau par les [&hellip;]<\/p>\n","protected":false},"author":26,"featured_media":28614,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[31],"class_list":["post-28619","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","tag-actualite-en"],"publishpress_future_action":{"enabled":false,"date":"2026-04-23 03:58:03","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/posts\/28619","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/comments?post=28619"}],"version-history":[{"count":2,"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/posts\/28619\/revisions"}],"predecessor-version":[{"id":28623,"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/posts\/28619\/revisions\/28623"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/media\/28614"}],"wp:attachment":[{"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/media?parent=28619"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/categories?post=28619"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.neurosciences.asso.fr\/en\/wp-json\/wp\/v2\/tags?post=28619"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}